An UVB-carcinogenesis Model with KSN Nude Mice.
نویسندگان
چکیده
منابع مشابه
Carcinomas in Nude Mice: A Model for Lung Carcinogenesis
We have previously described the neoplastic transformation of immor talized human bronchial epithelial cells (BEAS-2B) by the combination of the c-raf-1 and c-myc protooncogenes and the concomitant induction of neuron-specific enolase mRNA expression (A. Pfeifer et al., Proc. Nati. Acad. Sci. USA, 86:10075-10079,1989). In this paper we describe the morphological, biochemical, and immunohistoche...
متن کاملExperimental leprosy with nude mice.
In 1960, Shepard10) reported a model of experimental leprosy of mouse by means of footpad inoculation technic. This experimental leprosy has been widely utilized in the field of leprosy research, but grwoth of Mycobacterium leprae in normal mouse foot-pad is limited and maximum harvest of M. leprae from infected normal mouse foot-pad is about 106. Several studies were reported concerning immuno...
متن کاملLangerhans Cells Facilitate UVB-induced Epidermal Carcinogenesis
UVB light is considered the major environmental inducer of human keratinocyte (KC) DNA mutations, including within the tumor-suppressor gene p53, and chronic exposure is associated with cutaneous squamous cell carcinoma formation. Langerhans cells (LCs) comprise a dendritic network within the suprabasilar epidermis, yet the role of LCs in UVB-induced carcinogenesis is largely unknown. Herein we...
متن کاملPhotochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols.
Chronic exposure of the skin to ultraviolet B (UVB) radiation induces oxidative stress, which plays a crucial role in the induction of skin cancer. In this study, the effect of dietary feeding and topical application of brown algae polyphenols on UVB radiation-induced skin carcinogenesis in SKH-1 mice was investigated. SKH-1 hairless mice were randomly divided into 9 groups, including control, ...
متن کامل8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis.
8-Oxoguanine is one of the oxidative DNA damages that can result in stable mutations. The Ogg1 gene encodes the repair enzyme 8-oxoguanine-DNA glycosylase, which removes the oxidized base from DNA. In this study, we investigated the role of 8-oxoguanine in skin carcinogenesis induced by UVB irradiation using Ogg1 knockout mice (C57Bl/6J background). We examined the effect of UVB irradiation on ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 1998
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.39.73